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2026年5月22日Cancer Immunology, ImmunotherapyTGF-β inhibition enhances anti-tumor immunity and sensitizes PD-1 blockade therapy of bone marrow-derived myofibroblasts-induced “immunotherapy resistance” tumor model5.1成纤维细胞/免疫疗法转录组测序
mRNA测序
2026年3月17日Nature CommunicationsInhibition of the cancer stem cell immune checkpoint SOAT1 suppresses regulatory T cell functions through a trans-cellular 20(S)-Hydroxycholesterol-GPR132 pathway in mice15.7小鼠/肿瘤免疫逃逸转录组测序
mRNA测序
2026年4月24日Materials Today BioBioenergetic-active hybrid nanovesicles empower tumor associated macrophages phagocytosis for cancer immunotherapy10.2巨噬细胞;纳米囊泡转录组测序
mRNA测序
2026年5月1日eBioMedicineThe AGPS regulatory variant rs113671272 confers esophageal squamous cell carcinoma susceptibility through allele-specific MEIS3 binding and NF-κB activation in Chinese populations10.8细胞;食管鳞状细胞癌转录组测序
mRNA测序
2025年11月27日Clinical EpigeneticsDecoding epigenetic and transcriptional landscapes: DNA methylome-transcriptome integration reveals novel drivers in 4NQO-Induced esophageal squamous cell carcinoma mouse model4.4小鼠;食管鳞状细胞癌;肿瘤免疫微环境转录组测序
基因芯片
小鼠甲基化芯片;mRNA-seq
2026年3月20日cell death & diseaseAdipogenic transdifferentiation reprograms EMT-high PDAC cells into a post-mitotic adipocyte-like state and limits metastasis7.0胰腺导管腺癌;靶向免疫治疗转录组测序
表观&互作组测序
ATAC测序;mRNA测序
2025年10月27日Frontiers in Cell and Developmental BiologyExtracellular matrix stiffness regulates the proliferation and migration capacities of lymphatic endothelial cells via FAT14.3小鼠转录组测序
mRNA测序
2025年10月2日Drug Design Development And TherapyModified Sijunzi Decoction Inhibits Pancreatic Cancer Progression and Improves Immune Suppression: Network Pharmacology and Experimental Validation5.1小鼠转录组测序
mRNA-seq
2025年9月30日Journal of Experimental & Clinical Cancer ResearchCancer-associated fibroblast promotes tamoxifen resistance in estrogen receptor positive breast cancer via exosomal LncRNA PRKCQ-AS1/miR-200a-3p/MKP1 axis-mediated apoptosis suppression12.8转录组测序
mRNA-seq
2025年8月14日Advanced ScienceHIFU-Driven Targeted Pyroptosis Therapy in Basal-Like Breast Cancer14.1小鼠转录组测序
mRNA-seq
2025年5月19日Journal of Integrative Medicine-JIMAstragaloside Ⅳ delayed the epithelial–mesenchymal transition in peritoneal fibrosis by inhibiting the activation of EGFR and PI3K-AKT pathways4.2小鼠细胞单细胞&空转测序
转录组测序
mRNAseq
2025年8月17日Biochem Biophys Res CommunMulti-omics Profiling Reveals Liver–Retina axis in High-Fat Diet-Induced Early Retinopathy2.5小鼠/视网膜转录组测序
mRNAseq
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